TNF Receptors Choose HSC Fate in Supporting Dnmt3a-Mutant Clonal Hematopoiesis.

Published in: Cancer discovery (2022)

TNFα receptor signaling distinctly promotes self-renewal and lymphoid differentiation in Dnmt3a-mutant hematopoietic stem cells, contributing to clonal hematopoiesis of indeterminate potential. See related article by SanMiguel et al., p. 2763 (3).

Keyphrases

stem cells
dna methylation
rheumatoid arthritis
wild type
bone marrow
hematopoietic stem cell
gene expression
human health
risk assessment
climate change
mesenchymal stem cells
fine needle aspiration
drug induced