Inhibition of the Wnt/β-catenin pathway enhances antitumor immunity in ovarian cancer.
David W DooSelene Meza-PerezAngelina I LondoñoWhitney N GoldsberryAshwini A KatreJonathan D BooneDylana J MooreCindy T HudsonIlaria BetellaTyler R McCawAbhishek GangradeRiyue BaoJason J LukeEddy S YangMichael J BirrerDmytro StarenkiSara J CooperDonald J BuchsbaumLyse A NorianTroy D RandallRebecca C ArendPublished in: Therapeutic advances in medical oncology (2020)
These findings suggest that inhibiting the Wnt/β-catenin pathway may have a potent immunomodulatory effect in the treatment of ovarian cancer, particularly when combined with paclitaxel.