Transcriptional signatures of synaptic vesicle genes define myotonic dystrophy type I neurodegeneration.
Antonio Jimenez-MarinIbai DiezGarazi LabayruAndone Sistiaga AMaria C CaballeroPol Andrés-BenitoJorge SepulcreIsidro FerrerAdolfo Lopez de MunainJesus María CortesPublished in: Neuropathology and applied neurobiology (2021)
The combination of large-scale transcriptome interactions with brain imaging and cognitive function sheds light on the neurobiological mechanisms of brain degeneration in DM1 that might help define future therapeutic strategies and research into this condition.
Keyphrases
- genome wide
- resting state
- white matter
- gene expression
- high resolution
- functional connectivity
- cerebral ischemia
- transcription factor
- early onset
- current status
- multiple sclerosis
- muscular dystrophy
- adipose tissue
- mass spectrometry
- heat shock
- blood brain barrier
- subarachnoid hemorrhage
- bioinformatics analysis
- prefrontal cortex
- glycemic control
- insulin resistance
- weight loss