Diagnosing myasthenia gravis using orthoptic measurements: assessing extraocular muscle fatiguability.
Kevin R KeeneJohan M de NieMechteld J BrinkIrene C NottingJan J G M VerschuurenHermien E KanJan-Willem M BeenakkerMartijn R TannemaatPublished in: Journal of neurology, neurosurgery, and psychiatry (2022)
Orthoptic measurements can be used to diagnose MG by quantifying EOM weakness and fatiguability. Drift during persistent gaze on a Hess chart is specific for MG and could be used for diagnostic purposes. The Hess chart examination is widely available, inexpensive and fast. Moreover, orthoptic measurements may be a clinically relevant outcome measure for clinical trials.