Genomic and Phenotypic Characterization of a Broad Panel of Patient-Derived Xenografts Reflects the Diversity of Glioblastoma.

Rachael Ann VaubelShulan TianDioval RemondeMark A SchroederAnn C MladekGaspar J KitangeAlissa CaronThomas M KollmeyerRebecca GroveSen PengBrett L CarlsonDaniel J MaGobinda SarkarLisa EversPaul A DeckerHuihuang YanHarshil D DhruvMichael E Berens Qiang-Hu Wang Bianca M MarinEric W KleeAndrea CalifanoDaniel H LaChanceJeanette E Eckel-PassowRoel G VerhaakErik P SulmanTerry C BurnsFredrick B MeyerBrian P O'NeillNhan L TranCaterina GianniniRobert B JenkinsIan F ParneyJann N Sarkaria

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

Our PDX panel captures the molecular heterogeneity of glioblastoma and recapitulates many salient genetic and phenotypic features. All models and genomic data are openly available to investigators.

Keyphrases

copy number
genome wide
electronic health record
single cell
big data
dna methylation
machine learning