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Metagenomics-driven rapid diagnosis of an imported fatal case of rare amoebic meningoencephalitis.

Qingtian GuanBushra AlhuthaliSara MfarrejMagid Abdel HalimReem S AlmaghrabiArnab Pain
Published in: Journal of travel medicine (2021)
We identified Naegleria fowleri as the aetiologic agent from cerebrospinal fluid (CSF) of a patient with a travel history to Karachi. We demonstrate the benefit of metagenomics-based rapid diagnosis of primary amoebic meningoencephalitis (PAM) when routine clinical tests fail to provide a definitive diagnosis. We reconstructed the N. fowleri genome.
Keyphrases
  • cerebrospinal fluid
  • squamous cell carcinoma
  • gene expression
  • dna methylation
  • radiation therapy
  • rectal cancer
  • quantum dots
  • infectious diseases