Hybrid immunity in older adults is associated with reduced SARS-CoV-2 infections following BNT162b2 COVID-19 immunisation.

Scott John Charles PallettJoseph HeskinFergus KeatingAndrea MazzellaHannah TaylorAatish PatelGeorgia LambDeborah SturdyNatalie EislerSarah DennyEsmita CharaniPaul RandellNabeela MughalEleanor ParkerCarolina Rosadas de OliveiraMichael RaymentRachael JonesRichard TedderMyra McClureElisabetta GroppelliGary W DaviesMatthew K O'SheaLuke S P Moore

Published in: Communications medicine (2023)

Hybrid immunity in older adults was associated with considerably higher antibody titres, neutralisation and inhibition capacity. Instances of high anti-RBD titre with lower inhibition suggests antibody quantity and quality as independent potential correlates of protection, highlighting added value of measuring inhibition over antibody titre alone to inform vaccine strategy.

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