Microstructural changes in the trigeminal nerve of patients with episodic migraine assessed using magnetic resonance imaging.
Tiffani J MungovenNoemi MeylakhKasia K MarciszewskiVaughan G MacefieldPaul M MaceyLuke A HendersonPublished in: The journal of headache and pain (2020)
Migraine pathophysiology is associated with microstructural abnormalities within the trigeminal nerve that are consistent with histological evidence of altered myelin and/or organization. These peripheral nerve changes may provide further insight into migraine pathophysiology and enable a greater understanding for targeted treatments of pain alleviation.