Genetic and epigenetic analysis of hepatocellular adenomas with atypical morphological features.

Simon HaefligerJuergen HenchColm J O'RourkeNathalie Meyer-SchallerSarp UzunJoan SaldarriagaAchim WeberLuca MazzucchelliPhilip JermannStephan FrankJesper B AndersenLuigi TerraccianoChristine SempouxMatthias S Matter

Published in: Histopathology (2022)

In our series, mutational, DNA methylation, as well as CNV analyses supported a relationship of atypical HCAs with non-atypical HCAs rather than with HCC. Therefore, in cases with difficult differential diagnosis between HCC and HCA, it might be advisable to perform targeted sequencing and/or combined methylation/copy number profiling.

Keyphrases

copy number
dna methylation
genome wide
mitochondrial dna
gene expression
single cell
cancer therapy
drug delivery