Pharmacokinetics of cefoperazone/sulbactam in critically Ill thrombotic thrombocytopenic purpura patients undergoing therapeutic plasma exchange.

Haitao LiChunlu GaoLiwang LinGensheng ZhangShengjin FanXin Hai

Published in: Journal of clinical pharmacy and therapeutics (2022)

TPE enhances the clearance of CFP and SUL in critically ill TTP patients. CFP is more likely to be removed than SUL due to its a low V and high Pb. TPE is suggested to begin 1-2 h after the end of CFP/SUL infusion. Plasma concentration monitoring is advised when CFP/SUL must be administered during TPE.

Keyphrases

patients undergoing
end stage renal disease
ejection fraction

newly diagnosed
chronic kidney disease
prognostic factors

low dose
heavy metals

patient reported
aqueous solution