Fabrication, characterization and evaluation of a new designed botulinum toxin-cell penetrating peptide nanoparticulate complex.

Nazanin Shabani RavariMaryam Ghareh SheikhlouNavid GoodarziBahar KharazianMohsen AminiFatemeh AtyabiSaman A NasrollahiRassoul Dinarvand

Published in: Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences (2023)

Using PEC method allowed us to form nanocomplex from proteins, and peptides without a covalent bond and harsh conditions. The muscle-weakening effect of toxin in CPP-BoNT/A nanocomplexes showed acceptable efficacy and extended-release pattern.

Keyphrases

botulinum toxin
escherichia coli
single cell
skeletal muscle
cell therapy
low cost
mesenchymal stem cells
transition metal