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Development and applications of peri-implantitis mouse models.

Jianwei ZhangZian TongLong ChenYinjie QianYifan LuQianming ChenMisi Si
Published in: Oral diseases (2024)
Most researchers have induced peri-implantitis by silk ligatures. Some others have induced peri-implantitis by Pg gavage and LPS injection. Current applications of peri-implantitis mouse models are in the following areas: investigation of pathogenesis and exploration of new interventions, comparison of peri-implantitis with periodontitis, the interaction between systemic diseases and peri-implantitis, etc. CONCLUSION: Silk ligature for 2-4 weeks, Pg gavage for 6 weeks, and LPS injection for 6 weeks all successfully induced peri-implantitis in mice. Mice have the advantages of mature gene editing technology, low cost, and short time to induce peri-implantitis. It has applications in the study of pathogenesis, non-surgical treatments, and interactions with other diseases. However, compared with large animals, mice also have a number of disadvantages that limit their application.
Keyphrases
  • high glucose
  • low cost
  • diabetic rats
  • inflammatory response
  • drug induced
  • type diabetes
  • metabolic syndrome
  • skeletal muscle
  • clinical evaluation