Heparin impairs skeletal muscle glucose uptake by inhibiting insulin binding to insulin receptor.
Canjun ZhuZhiyue XuYexian YuanTao WangChang XuCong YinPeipei XiePingwen XuHui YeNirali PatelSarah SchaulLina WangXiaotong ZhuSongbo WangPing GaoQianyun XiYongliang ZhangGang ShuQingyan JiangPublished in: Endocrinology, diabetes & metabolism (2021)
Heparin reduced insulin binding to its receptor by interacting with insulin and inhibited insulin-mediated activation of the PI3K/Akt signalling pathway in skeletal muscle, which leads to impaired glucose uptake and hyperglycaemia.