Login / Signup

Treating activated regulatory T cells with pramipexole protects human dopaminergic neurons from 6-OHDA-induced degeneration.

Adrián Guevara-SalinasCitlalli NetzahualcoyotziDiana Denisse Álvarez-LuquínErandi Pérez-FigueroaEdgar E Sevilla-ReyesCarlos Castellanos-BarbaVera Teresa Vega-ÁngelesEdgar Terán-DávilaEnrique EstudilloIván VelascoLaura Adalid-Peralta
Published in: CNS neuroscience & therapeutics (2024)
Anti-CD3/CD28-activated Treg cells protect dopaminergic neurons against 6-OHDA-induced damage. In addition, activated, IL-10-producing, pramipexole-treated Tregs also induced a neuroprotective effect, and the supernatants of these co-cultures promoted axonal growth. Pramipexole-treated, activated Tregs altered their gene expression in a concentration-dependent manner, and enhanced TGFβ-related dopamine receptor regulation and immune-related pathways. These findings open new perspectives for the development of immunomodulatory therapies for the treatment of PD.
Keyphrases
  • regulatory t cells
  • gene expression
  • high glucose
  • diabetic rats
  • endothelial cells
  • drug induced
  • oxidative stress
  • dendritic cells
  • epithelial mesenchymal transition
  • cell proliferation
  • subarachnoid hemorrhage