Long noncoding RNA Regulating ImMune Escape regulates mixed lineage leukaemia protein-1-H3K4me3-mediated immune escape in oesophageal squamous cell carcinoma.

Jia LiuWei-Yi ZhouXiao-Jing LuoYan-Xing ChenChau-Wei WongZe-Xian LiuJia- Bo ZhengHai- Yu MoJun-Quan ChenJia-Jun LiMing ZhongYu-Hong XuQi-Hua ZhangHeng-Ying PuQi-Nian WuYing JinZi-Xian Wang Rui-Hua Xu Hui-Yan Luo

Published in: Clinical and translational medicine (2023)

This study reveals that the RIME-MLL1-H3K4me3 axis plays a critical role in tumour immunosuppression. Moreover, RIME appears to be a potential prognostic biomarker for immunotherapy and developing drugs that target RIME may be a new therapeutic strategy that overcomes immunotherapy resistance and benefits patients with ESCC.

Keyphrases

long noncoding rna
squamous cell carcinoma
protein protein
acute myeloid leukemia
small molecule
binding protein
amino acid
radiation therapy
climate change