Maternal thiopurine metabolism during pregnancy in inflammatory bowel disease and clearance of thiopurine metabolites and outcomes in exposed neonates.

Emma K FlanaganEmily K WrightWinita HardikarMiles Patrick SparrowWilliam R ConnellMichael A KammPeter De CruzSteven J BrownAlexander ThompsonAnthea GreenwayIan WestleyMurray L BarclayAlyson L RossKaterina V KiburgSally J Bellnull null

Published in: Alimentary pharmacology & therapeutics (2021)

6-TGN levels decrease and 6-MMP levels increase in the second trimester of pregnancy. Infants are exposed to thiopurine metabolites at low levels with clearance by 6 weeks and no anaemia. The cause of infant thrombocytosis and abnormal liver biochemistry in the absence of metabolites is unclear.

Keyphrases

ms ms
pregnancy outcomes
type diabetes
pregnant women
metabolic syndrome
insulin resistance