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Systems biology combining human- and animal-data miRNA and mRNA data identifies new targets in ureteropelvic junction obstruction.

Theofilos PapadopoulosAudrey CasemayouEric NeauBenjamin BreuilCécile CaubetDenis CaliseBarbara A ThornhillMagdalena BachvarovaJulie BelliereRobert L ChevalierPanagiotis MoulosDimcho BachvarovBenedicte Buffin-MeyerStéphane DecramerFrançoise Conte AuriolJean-Loup BascandsJoost P SchanstraJulie Klein
Published in: BMC systems biology (2017)
Our study is the first to correlate a mouse model of neonatal partial UUO with human UPJ obstruction in a comprehensive systems biology analysis. Our data revealed let-7a and miR-29b as molecules potentially involved in the development of fibrosis in UPJ obstruction via the control of DTX4 in both man and mice that would not be identified otherwise.
Keyphrases
  • endothelial cells
  • electronic health record
  • mouse model
  • big data
  • type diabetes
  • genome wide
  • gene expression
  • machine learning
  • dna methylation
  • metabolic syndrome
  • adipose tissue
  • binding protein
  • high fat diet induced