Drugs That Interact With Colchicine Via Inhibition of Cytochrome P450 3A4 and P-Glycoprotein: A Signal Detection Analysis Using a Database of Spontaneously Reported Adverse Events (FAERS).

Ainhoa Gómez-LumbrerasRichard D BoyceLorenzo Villa ZapataMalinda S TanPhilip D HanstenJohn HornDaniel C Malone

Published in: The Annals of pharmacotherapy (2023)

This study identifies numerous safety signals for colchicine and CYP3A4/P-gp inhibitor drugs. Avoiding the interaction or monitoring for toxicity in patients when co-prescribing colchicine and these agents is highly recommended.

Keyphrases

end stage renal disease
ejection fraction
primary care
newly diagnosed
prognostic factors
patient reported outcomes
loop mediated isothermal amplification
electronic health record
oxide nanoparticles