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Exploring the effect on primary endpoints in trials testing targeted therapy interventions for rheumatoid arthritis: a meta-epidemiological study on the appropriate use of a core outcome set.

Philip Rask Lage-HansenNikoletta SvendsenJamie J KirkhamSabrina Mai NielsenKirstine AmrisMaarten P T de WitMaarten BoersTorkell J EllingsenRobin Christensen
Published in: Annals of the rheumatic diseases (2024)
Within this dataset, it is evident that the conclusions concerning our primary objective were significantly influenced by both the amount and characteristics of missing data. Our data suggest that fatigue could be more important for the primary endpoint than previously assumed, but this is based on limited data.
Keyphrases
  • electronic health record
  • rheumatoid arthritis
  • big data
  • data analysis
  • artificial intelligence
  • depressive symptoms
  • disease activity
  • sleep quality