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A proposed update of African swine fever virus (genotype II) subgenotyping based on the central variable region (CVR) of Russian isolates.

Roman ChernyshevAlexey IgolkinAntoinette van SchalkwykNikolay ZinyakovIvan KolbinAndrey ShotinFedor KorennoyAlexander SpryginAli Mazloum
Published in: Archives of virology (2024)
African swine fever virus (ASFV) isolates are grouped and tracked through analysis of their central variable region (CVR) sequences. In this study, sequences of 70 ASFV isolates collected from different regions of Russia between 2018 and 2022 were analyzed. The analysis based on the CVR sequences indicated that the isolates belonged to three distinct groups. Group 1 shared 100% sequence identity to the isolate Georgia 2007/1. Group 5 had a C > A single-nucleotide polymorphism (SNP) at position 601, while group 13 is new and unique to the Far East of Russia, with five isolates from the Amur, Khabarovsk, and Primorsky regions. These findings demonstrate a new approach to phylogenomics and cladistics of ASFV isolates within genotype II on the basis of the CVR.
Keyphrases
  • genetic diversity
  • genome wide
  • gene expression
  • dna methylation
  • amino acid