Impact of distinct therapies on antibody response to SARS-CoV-2 vaccine in systemic lupus erythematosus.
Emily F N YukiEduardo F BorbaSandra G PasotoLuciana P SeguroMichelle LopesCarla G S SaadAna Cristina Medeiros-RibeiroClovis A SilvaDanieli C O de AndradeLeonard Vinci K de KupaLorena BetancourtIsabela BertoglioJuliana ValimCamilla HoffFrancisco F C FormigaTatiana PedrosaEsper G KallasNádia Emi AikawaEloisa S BonfaPublished in: Arthritis care & research (2021)
Sinovac-CoronaVac has a moderate immunogenicity in naïve-SLE patients with an excellent safety profile. We further demonstrate that HCQ may improve SC, whereas prednisone and MMF had a major deleterious effect in vaccine response reinforcing the need to investigate the role of temporary MMF withdrawn or a vaccine-booster dose[clinicaltrials.gov #NCT04754698].