Indomethacin has no effect on trigeminally provoked parasympathetic output.
Maike MöllerCelina SchröderStefanie Iwersen-BergmannJan MehnertArne MayPublished in: Cephalalgia : an international journal of headache (2021)
In our study, neither indomethacin nor ibuprofen had an inhibitory effect on the trigeminal autonomic reflex. We suggest that blocking this reflex may not be the treatment mechanism of indomethacin.