Identification and Targeting of Thomsen-Friedenreich and IL1RAP Antigens on Chronic Myeloid Leukemia Stem Cells Using Bi-Specific Antibodies.
Raghda E EldesoukiChengxiang WuFayez M SalehEman Abdel-Moemen MohammedSoha YounesNaglaa Elsayed HassanTheresa C BrownEckhard U AltJames E RobinsonFouad Mohamed BadrStephen E BraunPublished in: OncoTargets and therapy (2021)
These results show that the bi-specific antibody is capable of targeting IL1RAP+ and CD176+ cell population among CML PBMCs, but not corresponding normal cells in CDC assay. We hereby offer a novel strategy for the depletion of CML stem cells from the bulk population in clinical hematopoietic stem cell transplantation.
Keyphrases
- chronic myeloid leukemia
- stem cells
- induced apoptosis
- cancer therapy
- cell therapy
- single cell
- cell cycle arrest
- acute myeloid leukemia
- high throughput
- dendritic cells
- cell cycle
- oxidative stress
- drug delivery
- mesenchymal stem cells
- endoplasmic reticulum stress
- bone marrow
- signaling pathway
- pi k akt
- cell proliferation
- bioinformatics analysis