Pharmacological inhibition of N-Acylethanolamine acid amidase (NAAA) mitigates intestinal fibrosis through modulation of macrophage activity.
Maria Francesca NanìEster PaganoPaola De CiccoGiuseppe LucarielloFabio CattaneoFrancesca Paola TropeanoDonatella CiciaRebecca AmicoFederica RaucciGiuseppe ErcolanoFrancesco MaioneMaria Michela RinaldiFabiana EspositoRosario AmmendolaGaetano LuglioRaffaele CapassoAlexandros MakriyannisStefania PetrosinoFrancesca BorrelliBarbara RomanoAngelo A IzzoPublished in: Journal of Crohn's & colitis (2024)
Our findings provide new insights into the pathophysiological mechanism of intestinal fibrosis and identify NAAA as a promising target for the development of therapeutic treatments to alleviate CD fibrosis.