Circulating cell-free messenger RNA enables non-invasive pan-tumour monitoring of melanoma therapy independent of the mutational genotype.
Lea Jessica AlbrechtAnna HöwnerKlaus GriewankSmiths S LueongNils von NeuhoffPeter A HornAntje SuckerAnnette PaschenElisabeth LivingstoneSelma UgurelLisa ZimmerSusanne HornJens T SivekeDirk SchadendorfRenata VaraljaiAlexander RoeschPublished in: Clinical and translational medicine (2022)
In sum, we identified a new panel of cfRNAs for a pan-tumour liquid biopsy approach and demonstrated its utility as a prognostic, therapy-monitoring tool independent of the melanoma mutational genotype.