Novel Driver Strength Index highlights important cancer genes in TCGA PanCanAtlas patients.

Aleksey V BelikovAlexey D VyatkinSergey V Leonov

Published in: PeerJ (2022)

Our indices are able to select for driver gene attributes not selected by frequency sorting, potentially for driver strength. Genes and pathways prioritized are likely the strongest contributors to cancer initiation and progression and should become future therapeutic targets.

Keyphrases

papillary thyroid
genome wide
genome wide identification
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
dna methylation
genome wide analysis
transcription factor
childhood cancer
patient reported outcomes