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DNA methylation reveals distinct cells of origin for pancreatic neuroendocrine carcinomas and pancreatic neuroendocrine tumors.

Tincy SimonPamela RiemerArmin JaroschKatharina DetjenAnnunziata Di DomenicoFelix BormannAndrea MenneSlim KhoujaNanna MonjéLiam H ChildsDido LenzeUlf LeserFlorian RossnerMarkus MorkelNils BlüthgenMarianne PavelDavid HorstDavid CapperIlaria MarinoniAurel PerrenSoulafa MamloukChristine Sers
Published in: Genome medicine (2022)
Our study provides a robust and clinically applicable method to clearly distinguish PanNECs from G3 PanNETs, improving patient stratification.
Keyphrases
  • neuroendocrine tumors
  • dna methylation
  • induced apoptosis
  • cell cycle arrest
  • gene expression
  • case report
  • genome wide
  • high grade
  • oxidative stress
  • endoplasmic reticulum stress
  • cell death