Interference with the HNF4-dependent gene regulatory network diminishes endoplasmic reticulum stress in hepatocytes.
Anit ShahIan HuckKaylia DuncanErica R GansemerKaihua LiuReed C AdajarUdayan ApteMark A StamnesD Thomas RutkowskiPublished in: Hepatology communications (2023)
Together, our findings suggest that the UPR regulates hepatocyte identity through HNF4α to protect ER homeostasis even at the expense of liver function.