First evidence of altered microbiota and intestinal damage and their link to absence epilepsy in a genetic animal model, the WAG/Rij rat.
Rita CitraroFrancesca LemboCarmen De CaroMartina TallaricoLorena CorettiLuigi Francesco IannoneAntonio LeoDomenico PalumboMariella CuomoElisabetta BuomminoValentina NesciNadia MarascioMichelangelo IannoneAngela QuirinoRoberto RussoAntonio CalignanoAndrew ConstantiEmilio RussoGiovambattista De SarroPublished in: Epilepsia (2021)
Our results demonstrate for the first time that the gut microbiota is modified and contributes to seizure occurrence in a genetic animal model of absence epilepsy and that its manipulation may be a suitable therapeutic target for absence seizure management.