Epigenetic markers in circulating cell-free DNA as prognostic markers for survival of castration-resistant prostate cancer patients.

Rianne J HendriksSiebren DijkstraFrank P SmitJohan VandersmissenHendrik Van de VoordePeter F A MuldersInge M van OortWim Van CriekingeJack A Schalken

Published in: The Prostate (2018)

In conclusion, this study showed the kinetics of methylated cfDNA (GSTP1 and APC) in plasma of CRPC patients after starting treatment. Furthermore, the value of the markers before treatment is prognostic for overall survival. These results are promising for developing a test to guide treatment-decision-making for CRPC patients.

Keyphrases

end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
dna methylation
patient reported outcomes
combination therapy