Identification of Sex-Specific Genetic Polymorphisms Associated with Asthma in Middle-Aged and Older Canadian Adults: An Analysis of CLSA Data.

Ugochukwu Odimba Ambikaipakan Senthilselvan Jamie Farrell Zhiwei Gao

Published in: Journal of asthma and allergy (2023)

We discovered novel sex-specific genetic markers in/near the KIF26B, RTN4, EPHB1, NMBR, SERP2, PEPD, and NFATC2 genes that could potentially shed light on the sex differences in asthma susceptibility in males and females. Future mechanistic studies are required to understand better the underlying sex-related pathways of the identified loci in asthma development.

Keyphrases

chronic obstructive pulmonary disease
lung function
genome wide
allergic rhinitis
bioinformatics analysis
physical activity
machine learning
big data
transcription factor
gene expression
artificial intelligence
data analysis
deep learning
community dwelling