Prognostic Value of 18 F-FDG PET/CT Volume-Based Metabolic Parameters in Patients with Node-Negative Stage II Esophageal Squamous Cell Carcinoma.
Daniel Hueng-Yuan ShenHung-Pin ChanFu-Ren TsaiChin HuAllan Yi-Nan ChenHung-Yen ChanChe-Hsin LeeKuo Pin ChuangMing-Hui YangYu-Chang TyanPublished in: Metabolites (2021)
Esophageal squamous cell carcinoma (ESCC) is a major cancer prevalent in Asian males. Pretreatment tumor burden can be prognostic for ESCC. We studied the prognostic value of metabolic parameters of 2-deoxy-2-[ 18 F] fluoro-D-glucose positron emission tomography/computed tomography ( 18 F-FDG PET/CT) and the serum squamous cell carcinoma antigen (SCC-Ag) level in node-negative stage II ESCC patients. Eighteen males underwent staging evaluation were included. The volume-based metabolic parameters derived from 18 F-FDG PET/CT, including metabolic tumor volume (MTV) and total lesion glycolysis (TLG), were obtained using the PET Volume Computer Assisted Reading application. The Spearman correlation coefficients were calculated to assess the relationship between metabolic parameters and pretreatment serum SCC-Ag levels. Based on the 5-year follow-up, patients were sub-divided into the demised and the stable groups. Potential prognostic value was assessed by independent t -test and the Mann-Whitney U test. The association of overall survival was assessed using univariate and multivariate Cox regression analyses. The demised group showed significant higher values in serum SCC-Ag, as well as in MTV and TLG, but not SUVmax and SUVmean. The SUVmax, MTV, TLG, and serum SCC-Ag showed significant association with overall survival. Our findings suggest potential usage of pretreatment volume-based metabolic parameters of 18 F-FDG PET/CT and serum SCC-Ag as prognostic factors for node-negative stage II ESCC patients.
Keyphrases
- prognostic factors
- positron emission tomography
- computed tomography
- end stage renal disease
- squamous cell carcinoma
- ejection fraction
- chronic kidney disease
- lymph node
- quantum dots
- peritoneal dialysis
- magnetic resonance imaging
- type diabetes
- pet ct
- risk assessment
- highly efficient
- patient reported outcomes
- pet imaging
- skeletal muscle
- contrast enhanced
- working memory
- human health
- patient reported
- lymph node metastasis