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Mosaic loss of Y chromosome in monocytes is associated with lower survival after transcatheter aortic valve replacement.

Silvia Mas-PeiroWesley T AbplanalpTina RasperAlexander BerkowitschDavid M LeistnerStefanie DimmelerAndreas M Zeiher
Published in: European heart journal (2023)
This is the first study to demonstrate that LOY in blood cells is associated with profoundly impaired long-term survival even after successful TAVR. Mechanistically, the pro-fibrotic gene signature sensitizing the patient-derived circulating LOY monocytes for the TGFβ signaling pathways supports a prominent role of cardiac fibrosis in contributing to the effects of LOY observed in men undergoing TAVR.
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