Mosaic loss of Y chromosome in monocytes is associated with lower survival after transcatheter aortic valve replacement.
Silvia Mas-PeiroWesley T AbplanalpTina RasperAlexander BerkowitschDavid M LeistnerStefanie DimmelerAndreas M ZeiherPublished in: European heart journal (2023)
This is the first study to demonstrate that LOY in blood cells is associated with profoundly impaired long-term survival even after successful TAVR. Mechanistically, the pro-fibrotic gene signature sensitizing the patient-derived circulating LOY monocytes for the TGFβ signaling pathways supports a prominent role of cardiac fibrosis in contributing to the effects of LOY observed in men undergoing TAVR.
Keyphrases
- transcatheter aortic valve replacement
- aortic stenosis
- aortic valve
- induced apoptosis
- signaling pathway
- copy number
- dendritic cells
- cell cycle arrest
- peripheral blood
- left ventricular
- systemic sclerosis
- genome wide
- transforming growth factor
- pi k akt
- ejection fraction
- heart failure
- coronary artery disease
- anti inflammatory
- dna methylation
- epithelial mesenchymal transition
- gene expression
- oxidative stress
- atrial fibrillation
- cell proliferation