Are radiological endpoints surrogate outcomes of overall survival in hepatocellular carcinoma treated with transarterial chemoembolization?
Ciro CelsaGiuseppe CabibboMarco EneaSalvatore BattagliaGiacomo Emanuele Maria RizzoAnita BusaccaPaolo GiuffridaCaterina StornelloGiuseppe BrancatelliRoberto CannellaSalvatore GruttadauriaCalogero CammàPublished in: Liver international : official journal of the International Association for the Study of the Liver (2021)
In studies of TACE for u-HCC, the surrogate relationship of radiology-based endpoints with OS is moderate. Multiple endpoints including hepatic decompensation, macrovascular invasion and extrahepatic spread are needed for future trials comparing systemic therapies or combination of TACE with systemic therapies vs TACE alone.