Parental preconception posttraumatic stress symptoms and maternal prenatal inflammation prospectively predict shorter telomere length in children.
Gabrielle R RinneJudith E CarrollChristine M GuardinoMadeleine U ShalowitzSharon Landesman RameyChristine Dunkel SchetterPublished in: Psychosomatic medicine (2023)
Maternal symptoms of PTSD prior to conception and second trimester inflammation were associated with shorter telomere length in offspring in early childhood, independent of covariates. Findings indicate intergenerational transmission of parental trauma may occur in part through accelerated biological aging processes and provide further evidence that prenatal pro-inflammatory processes program child telomere length.Open Science Framework Pre-registration:https://osf.io/7c2d5/?view_only=cd0fb81f48db4b8f9c59fc8bb7b0ef97.
Keyphrases
- pregnancy outcomes
- pregnant women
- oxidative stress
- birth weight
- public health
- young adults
- gestational age
- mental health
- sleep quality
- quality improvement
- preterm birth
- growth factor
- type diabetes
- posttraumatic stress disorder
- physical activity
- weight gain
- insulin resistance
- trauma patients
- nk cells
- diabetic nephropathy