Promising approach to reducing Malaria transmission by ivermectin: Sporontocidal effect against Plasmodium vivax in the South American vectors Anopheles aquasalis and Anopheles darlingi.

Yudi T PinillaStefanie C P LopesVanderson S SampaioFrancys S AndradeGisely C MeloAlessandra S OrfanóNágila F C SecundinoMaria G V B GuerraMarcus V G LacerdaKevin C KobylinskiKarin S Escobedo-VargasVictor M López-SifuentesCraig A StoopsG Christian BaldevianoJoel TarningGissella M VasquezPaulo F P PimentaWuelton Marcelo Monteiro

Published in: PLoS neglected tropical diseases (2018)

In conclusion, whole blood spiked with IVM reduced the infection rate of P. vivax in An. aquasalis and An. darlingi, and increased the mortality of mosquitoes. Plasma from healthy volunteers after IVM administration affect asexual P. vivax development. These findings support that ivermectin may be used to decrease P. vivax transmission.

Keyphrases

plasmodium falciparum
aedes aegypti
zika virus
drug administration
dengue virus
risk factors
coronary artery disease
gene therapy