Protein Analysis of the TGFBIR124H Mouse Model Gives Insight into Phenotype Development of Granular Corneal Dystrophy.

Marie V LukassenEbbe T PoulsenJack DonaghyEmilie H MogensenKathleen A ChristieHila RoshanravanLarry DeDionisoM Andrew NesbitTara MooreJan J Enghild

Published in: Proteomics. Clinical applications (2020)

It is proposed that the lowered expression level of mutant TGFBIp protein relative to WT protein is the direct cause of the missing development of corneal deposits in the mouse. The overall protein profiles of the corneas are not impacted by the reduced amount of TGFBIp. Altogether, this supports a partial reduction in mutated TGFBIp as a potential treatment strategy for GCD2.

Keyphrases

mouse model
binding protein
protein protein
amino acid
climate change
wild type
human health
combination therapy
replacement therapy
cataract surgery