Tumor Mutational Burden and PTEN Alterations as Molecular Correlates of Response to PD-1/L1 Blockade in Metastatic Triple-Negative Breast Cancer.

Romualdo Barroso-SousaTanya E KeenanSonia PernasPedro ExmanEsha JainAna Christina Garrido-CastroMelissa HughesBrittany BychkovskyRenato UmetonJanet L FilesNeal I LindemanLaura E MacConaillF Stephen HodiIan E KropDeborah DillonEric P WinerNikhil WagleNancy U LinElizabeth A MittendorfEliezer M Van AllenSara M Tolaney

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

Among patients with mTNBC treated with anti-PD-1/L1 therapies, high TMB and PTEN alterations were associated with longer and shorter survival, respectively. These observations warrant validation in larger datasets.

Keyphrases

pi k akt
cell proliferation
squamous cell carcinoma
small cell lung cancer
rna seq
free survival
single cell