Synthesis and Cytotoxic Property of Annonaceous Acetogenin Glycoconjugates.

Jing-Fang ShiPing WuXiao-Li ChengXiao-Yi Wei Zi-Hua Jiang

Published in: Drug design, development and therapy (2020)

The conjugation of a glucose or galactose to squamocin and bullatacin yields glycosyl derivatives with similar level of anticancer activity in tested cell lines. Further studies are needed to demonstrate whether or not these compounds show reduced toxicity to normal cells and their therapeutic potential as antitumor agents.

Keyphrases

induced apoptosis
cell cycle arrest
oxidative stress
blood glucose
endoplasmic reticulum stress
signaling pathway
case control
metabolic syndrome
cell death
type diabetes
adipose tissue
insulin resistance
cell proliferation
glycemic control