Cardiometabolic Risk Factors for COVID-19 Susceptibility and Severity: A Mendelian Randomization Analysis.

Aaron Leong Joanne B ColeLaura N BrennerJames B Meigs Jose C Florez Josep Vicent Mercader

Published in: medRxiv : the preprint server for health sciences (2020)

Genetic evidence supports BMI as a causal risk factor for COVID-19 susceptibility and severity. This relationship may be mediated via type 2 diabetes. Obesity may have amplified the disease burden of the COVID-19 pandemic either single-handedly or through its metabolic consequences.

Keyphrases

type diabetes
coronavirus disease
sars cov
insulin resistance
weight gain
metabolic syndrome
weight loss
body mass index
cardiovascular disease
glycemic control
respiratory syndrome coronavirus
genome wide
gene expression
copy number
skeletal muscle