EGFR/IGF1R Signaling Modulates Relaxation in Hypertrophic Cardiomyopathy.
Sıla AlgülMaike SchuldtEmmy MandersValentijn JansenSaskia SchlossarekRichard de Goeij-de HaasAlexander A HennemanSander R PiersmaConnie R JiménezMichelle MichelsLucie CarrierMichiel HelmesJolanda van der VeldenDiederik W D KusterPublished in: Circulation research (2023)
We showed the feasibility of screening for functional modulators of cardiomyocyte relaxation and contraction, parameters that we observed to be modulated by kinases involved in EGFR/IGF1R, Akt, cell cycle signaling, and FoxO (forkhead box class O) signaling, respectively. Integrating the screening data with phosphoproteomics analysis in HCM patient tissue indicated that inhibition of EGFR/IGF1R signaling is a promising target for treating impaired relaxation in HCM.
Keyphrases
- hypertrophic cardiomyopathy
- cell cycle
- small cell lung cancer
- epidermal growth factor receptor
- cell proliferation
- tyrosine kinase
- transcription factor
- pi k akt
- left ventricular
- binding protein
- signaling pathway
- single molecule
- small molecule
- case report
- growth hormone
- electronic health record
- heart failure
- atrial fibrillation