Association between Statins Prescribed for Primary and Secondary Prevention and Major Adverse Cardiac Events among Older Adults with Frailty: A Systematic Review.

Matthew HaleHadar ZamanDavid MehdizadehOliver ToddHarriet CallaghanChris P GaleAndrew Clegg

Published in: Drugs & aging (2020)

This review identified only observational evidence that among older people with frailty, statins are associated with reduced mortality when prescribed for secondary prevention, and an absence of evidence evaluating statin therapy for primary prevention. Randomised trial data are needed to better inform the use of statins among older adults living with frailty.

Keyphrases

cardiovascular disease
community dwelling
cardiovascular events
left ventricular
electronic health record
coronary artery disease
type diabetes
open label
big data
clinical trial
emergency department
risk factors
machine learning
adverse drug