Genetic variants associated with white blood cell count amongst individuals with sickle cell disease.

Aderson da Silva AraújoYuelong GuoIsabel GomesBarbara MaltaAndré Rolim BelisárioLuiz AmorimDahra TelesMiriam ParkShannon KellyEster C SabinoGrier P PageBrian CusterCarla Luana Dinardonull null

Published in: British journal of haematology (2024)

Genetics plays an important role in regulating WBC count in patients with SCD. Our results point to possible mechanisms involved in WBC count variation and as increased WBC count is associated with more severe SCD, these results could suggest potential therapeutic targets for individuals with SCD.

Keyphrases

peripheral blood
single cell
cell therapy
early onset
bone marrow