Decreasing fluconazole susceptibility of clinical South African Cryptococcus neoformans isolates over a decade.
Serisha D NaickerRuth S MpembeTsidiso G MaphangaThokozile G ZuluDaniel DesantoJeannette WadulaNomonde MvelaseCaroline MalulekaKessendri ReddyHalima DawoodMotlatji MalobaNelesh P Govendernull nullPublished in: PLoS neglected tropical diseases (2020)
Fluconazole MIC50 and MIC90 values were two-fold higher in 2017 compared to 2007-2008. Although there are no breakpoints, higher fluconazole doses may be required to maintain efficacy of standard treatment regimens for cryptococcal meningitis.
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