Brain and spinal cord lesions in 28 inbred strains of aging mice.
Jerrold M WardPeter VogelJohn P SundbergPublished in: Veterinary pathology (2022)
Brain and spinal cord histopathology findings in male and female 20-month-old mice in a large-scale aging study of 28 inbred Jackson Laboratory mouse strains from 7 genetic families are described. Brain sections from selected strains at 12 and 24 months of age or older were also reviewed. Common lesions include axonal dystrophy in the gracile and/or cuneate nucleus in the sensory tract of the dorsal medulla and in the spinal cord in all strains. Hirano-like bodies were seen in 24/28 strains, and mineralization was observed in the thalamus of 9/28 strains. Less common lesions were also seen in the cerebellum, cerebral cortex, and other brain areas. No brain or spinal cord tumors were found. Evidence of an impairment of the ubiquitin-proteasome system (UPS) and/or suspected autophagy was manifested as medullary axonal dystrophy with intra-axonal granular eosinophilic bodies and LC3B immunohistochemistry in most strains. RIIIS/J, the most severely affected strain, showed moderate axonal dystrophy at 12 months, which progressed to severe lesions at 20 months. Comparative pathology in various species is discussed.
Keyphrases
- spinal cord
- spinal cord injury
- escherichia coli
- resting state
- neuropathic pain
- white matter
- functional connectivity
- cerebral ischemia
- early onset
- oxidative stress
- type diabetes
- subarachnoid hemorrhage
- signaling pathway
- high intensity
- physical activity
- genome wide
- adipose tissue
- gene expression
- dna methylation
- small molecule
- endoplasmic reticulum stress
- optic nerve
- high fat diet induced
- copy number
- drug induced
- genetic diversity