MRI-Guided Focused Ultrasound Blood-Brain Barrier Opening Increases Drug Delivery and Efficacy in a Diffuse Midline Glioma Mouse Model.

Payton J MartinezGenna NaultJenna SteinerMichael F WempeAngela PierceBreaunna BruntMathew SladeAndrew MonginJane SongKang-Ho SongNicholas EllensNatalie SerkovaAdam GreenMark Borden

Published in: bioRxiv : the preprint server for biology (2023)

FUS and microbubbles can increase the delivery of panobinostat to a patient-derived xenograft (PDX) orthotopic DMG tumor, providing a strong therapeutic effect and increased survival.

Keyphrases

blood brain barrier
mouse model
drug delivery
magnetic resonance imaging
contrast enhanced
cerebral ischemia
low grade
cancer therapy
diffusion weighted imaging
histone deacetylase
free survival
computed tomography