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Investigating the physiology of normothermic ex vivo heart perfusion in an isolated slaughterhouse porcine model used for device testing and training.

Benjamin KapplerCarlos A LedezmaSjoerd van TuijlVeronique MeijborgBastiaan J BoukensBülent ErginP J TanMarco StijnenCan InceVanessa Díaz-ZuccariniBas A J M de Mol
Published in: BMC cardiovascular disorders (2019)
The PhysioHeart™ is an acute model, suitable for cardiac device and therapy assessment, which can precede conventional animal studies. However, observations indicate that ex vivo slaughterhouse hearts resemble cardiac physiology of deteriorating hearts in a multi-organ failure situation and signalize the need for plasma clearance during perfusion to attenuate time-dependent function degradation. The presented study therefore provides an in-dept understanding of the sources and reasons causing the cardiac function loss, as a first step for future effort to prolong cardiac perfusion in the PhysioHeart™. These findings could be also of potential interest for other cardiac platforms.
Keyphrases
  • left ventricular
  • heart failure
  • contrast enhanced
  • stem cells
  • magnetic resonance imaging
  • atrial fibrillation
  • drinking water
  • risk assessment
  • drug induced
  • virtual reality
  • replacement therapy