Safety and pharmacokinetics of naringenin: A randomized, controlled, single-ascending-dose clinical trial.

Candida J RebelloRobbie A BeylJuan J L LertoraFrank L GreenwayEric RavussinDavid M RibnickyAlexander PoulevBrandon J KennedyHector F CastroShawn R CampagnaAnn A CoulterLeanne M Redman

Published in: Diabetes, obesity & metabolism (2019)

Ingestion of 150 to 900 mg doses of naringenin is safe in healthy adults, and serum concentrations are proportional to the dose administered. Since naringenin (8 μM) is effective in primary human adipocytes, ingestion of 300 mg naringenin twice/d will likely elicit a physiological effect.

Keyphrases

clinical trial
endothelial cells
pulmonary artery
open label
type diabetes
induced pluripotent stem cells
phase ii
double blind
pulmonary hypertension