Performance of the paracetamol-aminotransferase multiplication product in risk stratification after paracetamol (acetaminophen) poisoning: a systematic review and meta-analysis.
Chun En YauHaoyang ChenBryant Po-Yuen LimMingwei NgR PonampalamDaniel Yan Zheng LimYip Han ChinAndrew Fu-Wah HoPublished in: Clinical toxicology (Philadelphia, Pa.) (2022)
In this first meta-analysis, paracetamol × aminotransferase demonstrates its use in prognosticating hepatotoxicity in patients with paracetamol poisoning. It complements the Rumack-Matthew nomogram as it has shown promise in addressing two key limitations of the nomogram: it is usable after more than 24 h between overdose and acetylcysteine treatment, and it is applicable in staggered ingestions.