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Reconstructing the evolution history of networked complex systems.

Junya WangYi-Jiao ZhangCong XuJiaze LiJiachen SunJia-Rong XieLing FengTianshou ZhouYanqing Hu
Published in: Nature communications (2024)
The evolution processes of complex systems carry key information in the systems' functional properties. Applying machine learning algorithms, we demonstrate that the historical formation process of various networked complex systems can be extracted, including protein-protein interaction, ecology, and social network systems. The recovered evolution process has demonstrations of immense scientific values, such as interpreting the evolution of protein-protein interaction network, facilitating structure prediction, and particularly revealing the key co-evolution features of network structures such as preferential attachment, community structure, local clustering, degree-degree correlation that could not be explained collectively by previous theories. Intriguingly, we discover that for large networks, if the performance of the machine learning model is slightly better than a random guess on the pairwise order of links, reliable restoration of the overall network formation process can be achieved. This suggests that evolution history restoration is generally highly feasible on empirical networks.
Keyphrases
  • machine learning
  • protein protein
  • small molecule
  • healthcare
  • deep learning
  • artificial intelligence
  • mental health
  • big data
  • mass spectrometry
  • single cell
  • rna seq